High-purity shark chondroitin sulfate ndi chinthu chofunika kwambiri pa chithandizo chamankhwala
Chondroitin sulfate (CS) ndi glycosaminoglycan yofunikira yomwe imagwirizana kwambiri ndi mapuloteni kuti apange proteoglycans.Imagawidwa kwambiri mu matrix a extracellular ndi ma cell a minofu ya nyama, ndipo ndi gawo lofunikira kwambiri pamagulu olumikizana ndi nyama, omwe amakhala ochuluka kwambiri mu cartilage.Mapangidwe a chondroitin sulfate amapangidwa ndi kusinthasintha kwa D-glucuronic acid ndi N-acetylgalactosamine ndi ma glycosidic bonds, omwe amalumikizananso ndi gawo lapakati la mapuloteni kuti apange dongosolo la proteoglycan.
Chondroitin sulphate yochokera ku Shark ndi imodzi mwa izo, yomwe ndi acidic mucopolysaccharide yopangidwa kuchokera ku minofu ya shark cartilage.Zikuwoneka ngati ufa woyera kapena woyera, wopanda fungo, kukoma kosalowerera.Chondroitin shark sulfate ndi chimodzi mwa zigawo zikuluzikulu za mammalian connective minofu, ndipo imapezeka kwambiri mu cartilage, fupa, tendons, ligaments, sarcolemma, ndi makoma a mitsempha ya magazi.
Zimagwira ntchito ngati kusungirako ndikuthandizira mu cartilage ya articular.Kudya pang'ono kwa chondroitin sulphate kungathandize kusunga minofu ya cartilage, kuchepetsa kutupa ndi kupweteka, kumapangitsa kuti mafupa asamagwire bwino ntchito, komanso kukhala ndi chitetezo chokwanira.Nthawi zambiri amagwiritsidwa ntchito limodzi ndi glucosamine, kuphatikiza komwe kumapangitsa kuti pakhale kupweteka kwapakati kapena koopsa kwa osteoarthritis ndipo kumalimbikitsa kolajeni watsopano ndi proteoglycans mu chondrocytes.
| Dzina lazogulitsa | Shark Chondroitin Sulfate Soidum |
| Chiyambi | Chiyambi cha Shark |
| Quality Standard | USP40 Standard |
| Maonekedwe | Ufa woyera mpaka woyera |
| Nambala ya CAS | 9082-07-9 |
| Njira yopanga | njira ya enzymatic hydrolysis |
| Mapuloteni Okhutira | ≥ 90% ndi CPC |
| Kutaya pa Kuyanika | ≤10% |
| Mapuloteni Okhutira | ≤6.0% |
| Ntchito | Thandizo la Thanzi Lophatikizana, Cartilage ndi Bone Health |
| Kugwiritsa ntchito | Zakudya zowonjezera mu Tablet, Makapisozi, kapena Powder |
| Satifiketi ya Halal | Inde, Halal Yotsimikizika |
| Mkhalidwe wa GMP | NSF-GMP |
| Satifiketi Yaumoyo | Inde, satifiketi ya Zaumoyo ilipo pazachilolezo chamwambo |
| Shelf Life | Miyezi 24 kuyambira tsiku lopanga |
| Kulongedza | 25KG/Drum, Kulongedza Kwamkati: matumba a PE Awiri, Kulongedza Kwakunja: Drum Yapepala |
| ITEM | MFUNDO | NJIRA YOYESA |
| Maonekedwe | Ufa woyera wa crystalline | Zowoneka |
| Chizindikiritso | Chitsanzocho chimatsimikizira ndi laibulale yolozera | Ndi NIR Spectrometer |
| Mayamwidwe amtundu wa infrared a chitsanzo ayenera kuwonetsa maxima pamlingo wofanana ndi wa chondroitin sulfate sodium WS. | Ndi FTIR Spectrometer | |
| Kapangidwe ka ma disaccharides: Chiyerekezo cha mayankho apamwamba ku△DI-4S ku △DI-6S sichochepera 1.0 | Enzymatic HPLC | |
| Kuzungulira kwa Optical: Kukwaniritsa zofunikira pakuzungulira kwa kuwala, kusinthasintha kwapadera pamayeso apadera | Chithunzi cha SP781S | |
| Kuyesa (Odb) | 90% -105% | Mtengo wa HPLC |
| Kutaya Pa Kuyanika | < 12% | Chithunzi cha SP731 |
| Mapuloteni | <6% | USP |
| Ph (1%H2o Solution) | 4.0-7.0 | Chithunzi cha SP791 |
| Kuzungulira Kwapadera | -20 ° ~ -30 ° | Chithunzi cha SP781S |
| Residue On Ingition (Dry Base) | 20% -30% | Mtengo wa USP281 |
| Organic Volatile Residual | NMT0.5% | Chithunzi cha SP467 |
| Sulfate | ≤0.24% | Chithunzi cha USSP221 |
| Chloride | ≤0.5% | Chithunzi cha USSP221 |
| Kumveka (5%H2o Solution) | <0.35@420nm | USP38 |
| Electrophoretic Purity | NMT2.0% | Mtengo wa USP726 |
| Malire a palibe ma disaccharides enieni | ＜10% | Enzymatic HPLC |
| Zitsulo Zolemera | ≤10 PPM | ICP-MS |
| Total Plate Count | ≤1000cfu/g | USP2021 |
| Yisiti & Mold | ≤100cfu/g | USP2021 |
| Salmonella | Kusowa | USP2022 |
| E.Coli | Kusowa | USP2022 |
| Staphylococcus Aureus | Kusowa | USP2022 |
| Tinthu Kukula | Zosinthidwa malinga ndi zofunikira zanu | Mu Nyumba |
| Kuchulukana Kwambiri | > 0.55g/ml | Mu Nyumba |
Choyamba, chondroitin sulfate ndi glycosaminoglycan yomwe imapezeka kwambiri pamtundu wa extracellular wa minofu.M'mafupa, amapezeka makamaka m'mphepete mwa chondrocytes ndipo ndi gawo lofunika kwambiri la cartilage extracellular matrix.Mankhwalawa amathandiza kuti chichereŵechereŵe chikhale ndi madzi ndi zakudya zopatsa thanzi, motero kusunga chichereŵecheretsa chikhale chonyowa komanso chotanuka, ndikuthandizira kuti mafupa azikhala bwino.
Kachiwiri, physiological effect ya chondroitin sulfate ndiyofunikira kwambiri pakhungu la cartilage.Imatha kumanga mamolekyu amadzi, kutulutsa mamolekyu amadzi kukhala mamolekyu a proteoglycan, kulimbitsa chichereŵechereŵe ndikuwonjezera kuchuluka kwamadzimadzi a synovial mumtsempha wolumikizana, kudzoza ndi kuthandizira olowa.Mwa njira iyi, mgwirizanowu ukhoza kuchepetsa kukangana ndi kukhudzidwa pamene kusuntha, kotero kuti mgwirizanowu ukhoza kuyenda momasuka.
Pomaliza, chondroitin sulphate imagwiranso ntchito muumisiri wamafuta a mafupa.Ofufuzawa akonza ma hydrogel opangidwa ndi chondroitin sulfate, omwe amangomanga ma ion a inorganic ndikulimbikitsa kusinthika kwa mafupa, motero kumathandizira kusinthika kwa mafupa.Izi zili ndi ntchito zofunika pa opaleshoni yachipatala ya mafupa monga kukonza zolakwika za mafupa ndi kulumikiza mafupa.
1. Limbikitsani thanzi labwino: Chondroitin sulfate ndi chimodzi mwa zigawo zikuluzikulu za cartilage ya articular, zomwe zingathandize kuti articular cartilage ikhalebe yosalala ndi madzi, ndipo motero imasunga ntchito yachibadwa ya mgwirizano.Powonjezera ndi chondroitin sulfate, imatha kulimbikitsa kukonzanso ndi kusinthika kwa cartilage ya articular, motero kumachepetsa kusokonezeka kwa mgwirizano.
2. Kuchepetsa kupweteka kwa mgwirizano: chondroitin sulphate ikhoza kuchepetsa kuyankha kwa kutupa mu mgwirizano, kuchepetsa kukopa kwa mgwirizano wa synovium, ndiyeno kuchepetsa kupweteka kwa mgwirizano.Izi zimakhala ndi zotsatira zopweteka kwambiri kwa odwala omwe ali ndi matenda ophatikizana monga nyamakazi.
3. Kupititsa patsogolo kuyenda kwa mgwirizano: Chondroitin sulfate imapangitsa kuti kuyenda ndi kusinthasintha kwa mgwirizanowu powonjezera mafuta ophatikizana komanso kuchepetsa kukangana.Izi zimapangitsa kuti mgwirizano ukhale wosalala panthawi yoyenda, kuchepetsa kusokonezeka komwe kumachitika chifukwa cha kuuma kwa mgwirizano kapena kuyenda kochepa.
4. Tetezani articular cartilage: Chondroitin sulfate ikhoza kulepheretsa kuwonongeka kwa cartilage, ndikulimbikitsa kaphatikizidwe ndi katulutsidwe ka chondrocytes, kuti athe kuteteza articular cartilage.Izi zimathandiza kuchedwetsa ndondomeko ya ukalamba wa mafupa ndi kuwonongeka.
1. Kuchiritsa mabala ndi kukonza khungu: Chondroitin sulphate imagwira ntchito yofunika kwambiri pakuchiritsa mabala.Ikhoza kulimbikitsa kusinthika ndi kukonza minofu ya bala, kumapangitsa kuti khungu likhale lolimba komanso lolimba, ndikuthandizira kuchepetsa kupanga zipsera.Chifukwa chake, chondroitin sulphate imatha kugwiritsidwa ntchito popanga opaleshoni, kuwotcha komanso kukonza khungu.
2. Zodzoladzola zodzoladzola: Chifukwa cha zinthu zabwino zowonongeka komanso zotsutsana ndi ukalamba, chondroitin sulfate imagwiritsidwanso ntchito kwambiri m'makampani odzola.Zitha kuwonjezeredwa kuzinthu zosamalira khungu monga chinthu chonyowa, chomwe chimathandiza kuti khungu likhale bwino komanso kuti khungu likhale losalala komanso losalala.Kuphatikiza apo, chondroitin sulfate imathanso kulepheretsa kupanga ma free radicals, kuchepetsa ukalamba wa khungu, ndikupangitsa khungu kukhala locheperako komanso lathanzi.
3. Mankhwala opangira minofu ndi mankhwala obwezeretsanso: M'munda wa umisiri wa minofu ndi mankhwala obwezeretsanso, chondroitin sulfate imagwiritsidwa ntchito ngati chigawo cha zomangamanga za biomimetic stent.Zitha kuphatikizidwa ndi zinthu zina zamoyo kuti zipange ma scaffolds okhala ndi zida zenizeni ndi ntchito zokonzanso kapena kusinthanso minofu ndi ziwalo zowonongeka.The biocompatibility ndi bioactivity ya chondroitin sulphate imapangitsa kuti ikhale yofunika kwambiri pakupanga minofu.
4. Antitumor effect: M'zaka zaposachedwa, kafukufuku wapeza kuti chondroitin sulfate imakhalanso ndi mphamvu zotsutsana ndi zotupa.Itha kulepheretsa kuyambitsa ndi kupitilira kwa chotupa powongolera kukula, kusiyanitsa ndi njira za apoptotic zama cell chotupa.Ngakhale kuti kafukufuku wofunikira akadali woyambirira, chiyembekezo chogwiritsira ntchito chondroitin sulfate m'munda wa anti-chotupa chikuyembekezeka.
Chondroitin sulfate ndi glucosamine sulphate si a mitundu yofanana.Pali zosiyana mu kapangidwe kawo, kagwiritsidwe ntchito ndi kachitidwe kawo.
Chondroitin sulfate ndi glycosaminoglycan yokhala ndi zochitika zosiyanasiyana zamoyo, kuphatikizapo lipid-regulating and anti-inflammatory effects.Amagwiritsidwa ntchito kwambiri pochiza matenda a osteoarthritis ndipo amatha kuchepetsa oyimira pakati otupa ndi njira za apoptotic, pamene nthawi yomweyo amachepetsa kupanga cytokines yotupa, iNOS ndi MMPs.Kuphatikiza apo, chondroitin sulfate imathandizanso kwambiri pakuteteza ndi kukonza chiwombankhanga cha articular, kuthandiza kuti chichereŵechereŵe chiteteze kupsinjika kwapang'onopang'ono pamikhalidwe yosiyanasiyana yonyamula popangitsa kuti minofu ikhale yolimba komanso yotanuka.
Ndipo glucosamine sulfate ndi chinthu china chofunika kwambiri, chomwe chimagwiritsidwa ntchito makamaka popewa ndi kuchiza matenda osiyanasiyana a nyamakazi, monga mawondo a mawondo ndi chiuno.Imagwira pa articular cartilage, ndikulimbikitsa ma chondrocytes kupanga ma proteoglycans okhala ndi mawonekedwe abwinobwino a polysome, kuwongolera luso la chondrocytes, kuletsa kuwonongeka kwa ma enzymes a cartilage monga collagenase ndi phospholipase A2, ndipo kumatha kuletsa kupanga ma superoxidized free radicals m'maselo owonongeka, motero kuchedwa. The pathological ndondomeko ya osteoarthritis ndi kupita patsogolo kwa matenda, kusintha olowa ntchito, kuthetsa ululu.
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